Manufacturing PA Innovation Program Project Webinar
November 24, 2020
10:00 a.m. ET
Virtual
November 24, 2020
10:00 a.m. ET
Virtual
Speaker: Antonios Zavaliangos
Topic: Understanding, predicting and mitigating air entrapment defects in pharmaceutical tablet manufacturing
Sponsors: Drexel University with Merck
Pharmaceutical manufacturing of solid oral dosages faces several problems that stem from the need to balance the contradicting requirements of mechanical strength and bioavailability. This project focuses on understanding, predicting and mitigating defects that are caused by air entrapment during pharmaceutical tablet manufacturing. This problem has become increasingly common because many new active pharmaceutical ingredients (API) are produced in very fine (~micron) size to address limited solubility and meet bioavailability requirements. The presence of such fine powder in the tablet formulations in high volume percent restricts the displacement of the interstitial air during tablet compaction. The entrapped air is pressurized and upon release of the compaction load the internal pressure is often high enough to damage the tablets.
April 5 2024
10:30 AM - 3:00 PM ET
Manufacturing PA Innovation Program
Commonwealth Keystone Building, Harrisburg, PA
April 11-14 2024
Pittsburgh Campus
April 12 2024
2:00 PM - 4:00 PM ET
3rd Floor Collaboratory, Scott Hall